Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | CASP1 | P29466 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | CA3 | P07451 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | CA6 | P23280 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phloroglucinol SCHEMBL3118897 | 0.94 | ALDH1A1 (0.81) | ALDH1A1CA14CYP3A4HSD17B10CASP1 | |
| Benzidine SCHEMBL29155805 | 0.91 | CYP3A4 (0.65) | ALDH1A1CA14CYP3A4HSD17B10CASP1 | |
| SCHEMBL18894302 | 0.86 | ABL1 (0.67) | ALDH1A1CA14CYP3A4HSD17B10CASP1 | |
| Resorcinol SCHEMBL9114742 | 0.84 | CYP3A4 (0.71) | ALDH1A1CA14CYP3A4HSD17B10CASP1 | |
| 4-Aminophenol SCHEMBL4861305 | 0.81 | ALDH1A1 (1.00) | ALDH1A1CA14CYP3A4HSD17B10CASP1 | |
| SCHEMBL63371 | 0.81 | — | — | |
| 4-Aminophenol SCHEMBL3424 | 0.81 | — | — | |
| 4-Aminophenol SCHEMBL6753971 | 0.81 | ALDH1A1 (1.00) | ALDH1A1CA14CYP3A4HSD17B10CASP1 | |
| SCHEMBL2516281 | 0.80 | CYP19A1 (1.00) | ALDH1A1CA14CYP3A4HSD17B10CASP1 | |
| SCHEMBL2516283 | 0.80 | CYP19A1 (1.00) | ALDH1A1CA14CYP3A4HSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117219800-A | Composite proton exchange membrane and preparation method and application thereof | 中国石油大学(北京) | 2023-12-12 | — | — | CN | disclosed |