Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | RAD52 | P43351 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210514 | 0.81 | GAA (0.52) | MAPTGAAKDM4EGFERSMN1; SMN2 | |
| SCHEMBL8353109 | 0.80 | DRD2 (0.75) | MAPTGAARAD52KDM4EGFER | |
| SCHEMBL7684964 | 0.79 | HDAC6 (0.46) | MAPTGAAKDM4EGFERSMN1; SMN2 | |
| SCHEMBL2557098 | 0.78 | GAA (0.61) | MAPTGAARAD52KDM4EGFER | |
| Hydrochloric Acid SCHEMBL30753410 | 0.78 | ALDH1A1 (0.47) | MAPTGAAKDM4EGFERSMN1; SMN2 | |
| SCHEMBL5209026 | 0.78 | KCNH2 (0.47) | MAPTGAAKDM4EGFERSMN1; SMN2 | |
| SCHEMBL19538665 | 0.77 | TSHR (0.68) | MAPTGAARAD52KDM4EGFER | |
| SCHEMBL3016819 | 0.76 | ALDH1A1 (0.47) | MAPTGAAKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL24452939 | 0.75 | MAPT (0.67) | MAPTGAARAD52KDM4EGFER | |
| SCHEMBL578273 | 0.75 | GAA (0.67) | MAPTGAARAD52KDM4EGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597340-A | Substituted amino-aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| CN-117597336-A | Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |