Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.55 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29157650 | 1.00 | LSS (0.55) | LSSNPY5RMEN1KMT2ACYP3A4 | |
| SCHEMBL29157649 | 1.00 | LSS (0.55) | LSSNPY5RMEN1KMT2ACYP3A4 | |
| SCHEMBL24680782 | 0.82 | NPY5R (0.48) | LSSNPY5RMEN1KMT2AL3MBTL1 | |
| SCHEMBL29914459 | 0.82 | NPY5R (0.48) | LSSNPY5RMEN1KMT2AL3MBTL1 | |
| SCHEMBL24681150 | 0.82 | MCHR1 (0.59) | LSSNPY5RMEN1KMT2ANOTUM | |
| SCHEMBL13723675 | 0.78 | LSS (0.46) | LSSNPY5RMEN1KMT2ACYP3A4 | |
| SCHEMBL24681617 | 0.77 | CA1 (0.40) | LSSNPY5RCYP3A4PDE10APIK3CD | |
| SCHEMBL24681524 | 0.77 | CA1 (0.40) | LSSNPY5RCYP3A4PDE10APIK3CD | |
| SCHEMBL29914405 | 0.77 | CA1 (0.40) | LSSNPY5RCYP3A4PDE10APIK3CD | |
| SCHEMBL29914498 | 0.77 | ACVR1 (0.41) | NPY5RCYP3A4GPR119PDE10APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597340-A | Substituted amino-aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022226666-A1 | SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |