Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 4/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 5/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914459 | 1.00 | NPY5R (0.48) | NPY5RNOTUMHSD11B1RORCLSS | |
| SCHEMBL24681111 | 0.85 | NPY5R (0.45) | NPY5RNOTUMHSD11B1RORC | |
| SCHEMBL24680813 | 0.84 | NOTUM (0.47) | NPY5RNOTUMHSD11B1FPR1FPR2 | |
| SCHEMBL29914613 | 0.84 | NOTUM (0.47) | NPY5RNOTUMHSD11B1FPR1FPR2 | |
| SCHEMBL29157657 | 0.82 | LSS (0.55) | NPY5RNOTUMLSSMEN1KMT2A | |
| SCHEMBL29157649 | 0.82 | LSS (0.55) | NPY5RNOTUMLSSMEN1KMT2A | |
| SCHEMBL29157650 | 0.82 | LSS (0.55) | NPY5RNOTUMLSSMEN1KMT2A | |
| SCHEMBL24680793 | 0.80 | NOTUM (0.44) | NPY5RNOTUMFPR1FPR2 | |
| SCHEMBL31319987 | 0.80 | NOTUM (0.43) | NPY5RNOTUMRORCFPR2 | |
| SCHEMBL26881412 | 0.75 | NPY5R (0.56) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |