Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915322 | 0.87 | GRIN2B (0.41) | GRIN2BCXCR4NPBWR1MCHR1DRD2 | |
| SCHEMBL2915405 | 0.84 | GRIN2B (0.39) | GRIN2BCXCR4NPBWR1MCHR1DRD2 | |
| SCHEMBL2482262 | 0.76 | CYP19A1 (0.33) | TSHRTDP1CYP19A1 | |
| SCHEMBL2482409 | 0.73 | KMT2A (0.37) | POLBLMNA | |
| SCHEMBL2916318 | 0.71 | DRD2 (0.31) | DRD2 | |
| SCHEMBL2061002 | 0.67 | MAPT (0.36) | GRIN2BCXCR4DRD2DRD3OPRK1 | |
| SCHEMBL10035936 | 0.61 | MAPT (0.55) | POLB | |
| SCHEMBL8182158 | 0.60 | SPHK1 (0.36) | GRIN2BCXCR4OPRK1 | |
| SCHEMBL6052431 | 0.59 | ALDH1A1 (0.60) | TDP1L3MBTL1LMNA | |
| SCHEMBL2061291 | 0.59 | DRD2 (0.41) | GRIN2BDRD2DRD3DRD4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |