Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902808 | 0.92 | EGLN3 (0.50) | EGLN3KDM4EESR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2912072 | 0.91 | EGLN3 (0.52) | EGLN3KDM4EESR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3256900 | 0.90 | EGLN3 (0.48) | EGLN3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2911429 | 0.86 | KDM4E (0.61) | EGLN3KDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2897648 | 0.83 | EGLN3 (0.72) | EGLN3ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13074501 | 0.82 | EGLN3 (0.62) | EGLN3ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3260194 | 0.82 | EGLN3 (0.47) | EGLN3KDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2903007 | 0.81 | EGLN3 (0.60) | EGLN3ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3258148 | 0.81 | EGLN3 (0.50) | EGLN3KDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2903353 | 0.80 | ALDH1A1 (0.51) | EGLN3KDM4EALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298324-A1 | Prolyl Hydroxylase Inhibitors | SMITH KLINE BEECHAM CORPORATION (US) | 2010-11-25 | — | — | US | disclosed |
| EP-2240178-A1 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009086044-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITH KLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298324-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | EGLN3 2/4885KDM4E 206/4885ESR2 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.