Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3256900 | 0.91 | EGLN3 (0.48) | EGLN3TP53KDM4EALDH1A1HPGD | |
| SCHEMBL2912072 | 0.90 | EGLN3 (0.52) | EGLN3KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3260194 | 0.89 | EGLN3 (0.47) | EGLN3TP53KDM4EALDH1A1HPGD | |
| SCHEMBL3138128 | 0.84 | EGLN3 (0.70) | EGLN3TP53SMN1; SMN2MAPTMEN1 | |
| SCHEMBL3127714 | 0.83 | EGLN3 (0.60) | EGLN3TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL3135519 | 0.82 | EGLN3 (0.54) | EGLN3TP53KDM4EALDH1A1HPGD | |
| SCHEMBL2915918 | 0.81 | EGLN3 (0.50) | EGLN3KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3127230 | 0.80 | EGLN3 (0.56) | EGLN3TP53KDM4EALDH1A1HPGD | |
| SCHEMBL2902808 | 0.79 | EGLN3 (0.50) | EGLN3KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3133969 | 0.77 | EGLN3 (0.71) | EGLN3TP53ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059549-A1 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |