Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | CDK4 | P11802 | 2/20 | 0.30 |
| ▸ | CCND1 | P24385 | 2/20 | 0.30 |
| ▸ | CCND3 | P30281 | 2/20 | 0.30 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CCNH | P51946 | 1/20 | 0.30 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29163464 | 0.95 | MAPK1 (0.33) | MAPK1MAPKAPK2PDE3BPDE3ALRRK2 | |
| SCHEMBL29163280 | 0.95 | MAPK1 (0.33) | MAPK1MAPKAPK2PDE3BPDE3ALRRK2 | |
| SCHEMBL29163285 | 0.95 | MAPK1 (0.33) | MAPK1MAPKAPK2PDE3BPDE3ALRRK2 | |
| SCHEMBL29163343 | 0.94 | TNF (0.34) | MAPK1MAPKAPK2PDE3BPDE3ALRRK2 | |
| SCHEMBL29163360 | 0.92 | MAPK1 (0.38) | MAPK1MAPKAPK2PDE3BPDE3AGABRG2 | |
| SCHEMBL31079232 | 0.90 | MAPK1 (0.34) | MAPK1MAPKAPK2PDE3BPDE3ALRRK2 | |
| SCHEMBL29163283 | 0.90 | MAPK1 (0.34) | MAPK1PDE3BPDE3ALRRK2CDK4 | |
| SCHEMBL29163382 | 0.89 | MAPK1 (0.33) | MAPK1PDE3BPDE3ALRRK2CDK4 | |
| SCHEMBL27159896 | 0.88 | MAPK1 (0.39) | MAPK1MAPKAPK2GABRG2GABRB3GABRA5 | |
| SCHEMBL29163324 | 0.88 | MAPK1 (0.39) | MAPK1MAPKAPK2GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425479-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-12-26 | — | — | US | disclosed |
| CN-117597336-A | Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240425479-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | DCK, CMPK1, WNK1 | MAPK1 420/4885MAPKAPK2 176/4885PDE3B 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.