Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 13/20 | 0.60 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 7/20 | 0.56 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.50 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28575771 | 0.95 | IKZF2 (0.61) | IKZF2CRBNCSNK1A1GSPT1DDB1 | |
| SCHEMBL20231775 | 0.86 | IKZF2 (0.59) | IKZF2CRBNCSNK1A1GSPT1DDB1 | |
| SCHEMBL21760140 | 0.85 | IKZF2 (0.59) | IKZF2CRBNCSNK1A1GSPT1DDB1 | |
| SCHEMBL29167310 | 0.85 | CRBN (0.63) | IKZF2CRBNGSPT1DDB1 | |
| SCHEMBL30875990 | 0.84 | CRBN (0.56) | IKZF2CRBNCSNK1A1GSPT1DDB1 | |
| SCHEMBL29167347 | 0.84 | CRBN (0.56) | IKZF2CRBNCSNK1A1GSPT1DDB1 | |
| SCHEMBL27284779 | 0.83 | CRBN (0.56) | IKZF2CRBNCSNK1A1DDB1 | |
| SCHEMBL30930637 | 0.83 | CRBN (0.55) | IKZF2CRBNDDB1 | |
| SCHEMBL29767388 | 0.83 | CRBN (0.55) | IKZF2CRBNDDB1 | |
| SCHEMBL27284747 | 0.83 | CRBN (0.55) | IKZF2CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115626927-B | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-01-02 | — | — | CN | disclosed |