Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.46 |
| ▸ | MET | P08581 | 8/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885127 | 0.93 | AXL (0.47) | AXLALKMETPTK2INSR | |
| SCHEMBL884840 | 0.93 | AXL (0.47) | AXLALKMETPTK2INSR | |
| SCHEMBL886706 | 0.82 | INSR (0.66) | AXLALKMETINSR | |
| SCHEMBL884893 | 0.79 | ALK (0.60) | ALK | |
| SCHEMBL886310 | 0.78 | MET (0.52) | AXLALKMETPTK2INSR | |
| SCHEMBL2061330 | 0.76 | ALK (0.57) | ALKPTK2INSR | |
| SCHEMBL886704 | 0.76 | ALK (0.75) | ALKINSR | |
| SCHEMBL3006211 | 0.76 | AXL (0.56) | AXLALKMETPTK2INSR | |
| SCHEMBL24073715 | 0.76 | AXL (0.63) | AXLALKMETPTK2INSR | |
| SCHEMBL25834978 | 0.76 | AXL (0.63) | AXLALKMETPTK2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |