Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910903 | 0.80 | HTT (0.42) | GAAKDM4EMAPTL3MBTL1CYP19A1 | |
| SCHEMBL2910386 | 0.70 | TOP2A (0.37) | CYP19A1 | |
| SCHEMBL12130734 | 0.66 | PGR (0.39) | MAPTALDH1A1CYP19A1HRH3 | |
| SCHEMBL5891827 | 0.65 | CYP19A1 (0.36) | CYP19A1 | |
| SCHEMBL9090439 | 0.65 | CYP19A1 (0.55) | CYP19A1 | |
| SCHEMBL31554349 | 0.65 | AKR1C3 (0.33) | — | |
| SCHEMBL2474521 | 0.65 | GAA (0.48) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL9090407 | 0.64 | CYP19A1 (0.62) | CYP19A1SLC1A3SLC1A2 | |
| SCHEMBL7281806 | 0.63 | SMN1; SMN2 (0.31) | — | |
| Hydrochloric Acid SCHEMBL6781604 | 0.61 | PTGS2 (0.53) | ALOX5GAAKDM4EMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004657-B1 | CONDENSED IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2010-09-01 | — | — | EP | disclosed |