Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.47 |
| ▸ | INSR | P06213 | 12/20 | 0.47 |
| ▸ | IGF1R | P08069 | 12/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30875693 | 1.00 | ALK (0.47) | ALKINSRIGF1RCDK7CDK9 | |
| SCHEMBL25338974 | 0.91 | ALK (0.46) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL30183996 | 0.91 | ALK (0.46) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL25947566 | 0.84 | PRKDC (0.44) | ALKCDK9 | |
| SCHEMBL23932620 | 0.84 | ALK (0.53) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL24073495 | 0.81 | ALK (0.48) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL30223498 | 0.81 | ALK (0.48) | ALKINSRIGF1RMAP4K1EGFR | |
| SCHEMBL23154090 | 0.81 | INSR (0.49) | ALKINSRIGF1RCDK7CDK9 | |
| SCHEMBL29172303 | 0.80 | ALK (0.46) | ALKINSRIGF1RCDK7CDK9 | |
| SCHEMBL30184275 | 0.80 | ALK (0.46) | ALKINSRIGF1RCDK7CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117730083-A | Pyrimidine compounds as MAP4K1 inhibitors | 格兰马克专业公司 | 2024-03-19 | — | — | CN | disclosed |