Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.46 |
| ▸ | INSR | P06213 | 8/20 | 0.45 |
| ▸ | IGF1R | P08069 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29172303 | 1.00 | ALK (0.46) | ALKINSRIGF1RKMT2AMEN1 | |
| SCHEMBL23932620 | 0.86 | ALK (0.53) | ALKINSRIGF1RPTK2MAP4K1 | |
| SCHEMBL30184068 | 0.83 | ALK (0.45) | ALKINSRIGF1RPTK2MAP4K1 | |
| SCHEMBL29172314 | 0.83 | ALK (0.45) | ALKINSRIGF1RPTK2MAP4K1 | |
| SCHEMBL29172324 | 0.83 | INSR (0.46) | ALKINSRIGF1RPTK2MAP4K1 | |
| SCHEMBL25947586 | 0.83 | P2RX7 (0.45) | ALKKMT2AMEN1AGTR1RAB9A | |
| SCHEMBL17411151 | 0.82 | ALK (0.51) | ALKINSRIGF1RPTK2MAP4K1 | |
| SCHEMBL28949767 | 0.81 | ALK (0.48) | ALKINSRIGF1RPTK2MAP4K1 | |
| SCHEMBL30487106 | 0.81 | ALK (0.48) | ALKINSRIGF1RPTK2MAP4K1 | |
| SCHEMBL23153826 | 0.80 | ALK (0.47) | ALKINSRIGF1RPTK2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367123-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | Glenmark Specialty S.A. (CH) | 2024-05-15 | — | — | EP | disclosed |
| CN-117730083-A | Pyrimidine compounds as MAP4K1 inhibitors | 格兰马克专业公司 | 2024-03-19 | — | — | CN | disclosed |
| WO-2023281417-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALTY S.A. (CH) | 2023-01-12 | — | — | WO | disclosed |