Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLKL | Q8NB16 | 1/20 | 0.37 |
| ▸ | EML4 | Q9HC35 | 7/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.33 |
| ▸ | RET | P07949 | 6/20 | 0.33 |
| ▸ | ROS1 | P08922 | 6/20 | 0.33 |
| ▸ | FLT3 | P36888 | 6/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205576 | 0.89 | EML4 (0.32) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29173449 | 0.89 | BRD4 (0.32) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944970 | 0.87 | LCK (0.40) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24943828 | 0.86 | CDK2 (0.37) | SYK | |
| SCHEMBL30206306 | 0.85 | EML4 (0.33) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944980 | 0.85 | JAK3 (0.32) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24943847 | 0.85 | EML4 (0.32) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29173296 | 0.85 | EML4 (0.33) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30205538 | 0.85 | JAK3 (0.32) | EML4ALKRETROS1FLT3 | |
| Hydrochloric Acid SCHEMBL30206015 | 0.85 | EML4 (0.33) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |