Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 13/20 | 0.32 |
| ▸ | JAK2 | O60674 | 6/20 | 0.32 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 2/20 | 0.30 |
| ▸ | ROS1 | P08922 | 2/20 | 0.30 |
| ▸ | FLT3 | P36888 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205547 | 0.90 | EML4 (0.31) | EML4ALKJAK3SYKBTK | |
| SCHEMBL29173290 | 0.89 | MLKL (0.37) | BRD4EML4ALKSYKRET | |
| SCHEMBL30205698 | 0.87 | BTK (0.34) | EML4ALKJAK3SYKBTK | |
| SCHEMBL24944206 | 0.87 | BTK (0.34) | EML4ALKJAK3SYKBTK | |
| SCHEMBL24943828 | 0.86 | CDK2 (0.37) | JAK2JAK3SYKBTK | |
| SCHEMBL24944457 | 0.86 | EML4 (0.32) | EML4ALKSYKBTKRET | |
| SCHEMBL30206306 | 0.85 | EML4 (0.33) | JAK2EML4ALKJAK1SYK | |
| SCHEMBL24944980 | 0.85 | JAK3 (0.32) | EML4ALKJAK3SYKBTK | |
| SCHEMBL24943847 | 0.85 | EML4 (0.32) | EML4ALKSYKRETROS1 | |
| SCHEMBL29173296 | 0.85 | EML4 (0.33) | EML4ALKSYKRETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |