Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206025 | 1.00 | ALK (0.36) | ALKLRRK2CHEK1FGFR3EGFR | |
| SCHEMBL30206109 | 0.93 | LRRK2 (0.43) | LRRK2CHEK1EGFR | |
| SCHEMBL29173386 | 0.93 | LRRK2 (0.43) | LRRK2CHEK1EGFR | |
| SCHEMBL24944786 | 0.92 | IKBKE (0.38) | ALKEGFRCHRNA7MELKAXL | |
| SCHEMBL30205942 | 0.88 | CDK2 (0.39) | TGFBR1ACVR1MELKAXLCHKA | |
| SCHEMBL30206282 | 0.85 | LRRK2 (0.37) | LRRK2TLR7 | |
| SCHEMBL30206277 | 0.85 | LRRK2 (0.37) | LRRK2TLR7 | |
| SCHEMBL24944783 | 0.85 | LRRK2 (0.41) | ALKLRRK2EGFR | |
| SCHEMBL30206021 | 0.85 | LRRK2 (0.40) | LRRK2CHEK1EGFR | |
| SCHEMBL29173398 | 0.85 | LRRK2 (0.40) | LRRK2CHEK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |