Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205978 | 0.81 | PLAU (0.46) | NPSR1PGK1KDM4EPKMALDH1A1 | |
| SCHEMBL12389585 | 0.81 | PLAU (0.46) | NPSR1PGK1KDM4EPKMALDH1A1 | |
| SCHEMBL11727826 | 0.80 | NPSR1 (0.44) | NPSR1PGK1KDM4EPKMALDH1A1 | |
| SCHEMBL30206285 | 0.80 | NPSR1 (0.44) | NPSR1PGK1KDM4EPKMALDH1A1 | |
| SCHEMBL29173359 | 0.80 | NPSR1 (0.44) | NPSR1PGK1KDM4EPKMALDH1A1 | |
| SCHEMBL9091123 | 0.73 | NPSR1 (0.71) | NPSR1KDM4EPKMALDH1A1L3MBTL1 | |
| SCHEMBL21335829 | 0.73 | NPSR1 (0.44) | NPSR1KDM4EPKMALDH1A1L3MBTL1 | |
| SCHEMBL29206055 | 0.72 | NPSR1 (0.47) | NPSR1KDM4EPKMALDH1A1L3MBTL1 | |
| SCHEMBL25174331 | 0.71 | NPSR1 (0.54) | NPSR1KDM4EPKMALDH1A1L3MBTL1 | |
| SCHEMBL30792993 | 0.71 | NPSR1 (0.54) | NPSR1KDM4EPKMALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |