Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 15/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12389585 | 1.00 | PLAU (0.46) | PLAUNPSR1PGK1KDM4EPKM | |
| SCHEMBL21335829 | 0.88 | NPSR1 (0.44) | PLAUNPSR1KDM4EPKMALDH1A1 | |
| SCHEMBL8071643 | 0.86 | PLAU (0.46) | PLAUNPSR1KDM4EPKMALDH1A1 | |
| SCHEMBL29987712 | 0.83 | NPSR1 (0.54) | PLAUNPSR1KDM4EPKMALDH1A1 | |
| SCHEMBL507599 | 0.83 | NPSR1 (0.54) | PLAUNPSR1KDM4EPKMALDH1A1 | |
| SCHEMBL11151830 | 0.82 | GRM5 (0.55) | PLAUNPSR1KDM4EPKMALDH1A1 | |
| SCHEMBL1136751 | 0.82 | SCNN1A (0.53) | PLAUNPSR1KDM4EPKMALDH1A1 | |
| SCHEMBL29625000 | 0.82 | SCNN1A (0.53) | PLAUNPSR1KDM4EPKMALDH1A1 | |
| SCHEMBL11727826 | 0.81 | NPSR1 (0.44) | PLAUNPSR1PGK1KDM4EPKM | |
| SCHEMBL29173419 | 0.81 | NPSR1 (0.44) | PLAUNPSR1PGK1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |