Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173359 | 1.00 | NPSR1 (0.44) | NPSR1PGK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12389585 | 0.81 | PLAU (0.46) | NPSR1PGK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30205978 | 0.81 | PLAU (0.46) | NPSR1PGK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29173419 | 0.80 | NPSR1 (0.44) | NPSR1PGK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11727826 | 0.80 | NPSR1 (0.44) | NPSR1PGK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30206204 | 0.79 | NPSR1 (0.47) | NPSR1KDM4EALDH1A1SMN1; SMN2PKM | |
| SCHEMBL29173440 | 0.79 | NPSR1 (0.47) | NPSR1KDM4EALDH1A1SMN1; SMN2PKM | |
| SCHEMBL29173541 | 0.78 | NPSR1 (0.45) | NPSR1KDM4EALDH1A1SMN1; SMN2PKM | |
| SCHEMBL30205955 | 0.78 | NPSR1 (0.45) | NPSR1KDM4EALDH1A1SMN1; SMN2PKM | |
| SCHEMBL30206069 | 0.77 | NPSR1 (0.44) | NPSR1KDM4EALDH1A1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |