Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206129 | 1.00 | LRRK2 (0.37) | LRRK2ZAP70MEN1NPC1MAPT | |
| SCHEMBL24944968 | 0.92 | SYK (0.35) | LRRK2ZAP70 | |
| SCHEMBL29173596 | 0.91 | SYK (0.39) | LRRK2ZAP70MEN1NPC1MAPT | |
| SCHEMBL30206239 | 0.91 | SYK (0.39) | LRRK2ZAP70MEN1NPC1MAPT | |
| SCHEMBL29173428 | 0.88 | LRRK2 (0.36) | LRRK2ZAP70 | |
| SCHEMBL30206349 | 0.88 | LRRK2 (0.36) | LRRK2ZAP70 | |
| SCHEMBL29173445 | 0.87 | ZAP70 (0.43) | LRRK2ZAP70MEN1NPC1MAPT | |
| SCHEMBL29173569 | 0.86 | LRRK2 (0.37) | LRRK2ZAP70 | |
| SCHEMBL30206248 | 0.86 | LRRK2 (0.37) | LRRK2ZAP70 | |
| SCHEMBL30206194 | 0.85 | MEN1 (0.34) | LRRK2MEN1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |