Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206194 | 1.00 | MEN1 (0.34) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL29173596 | 0.92 | SYK (0.39) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL30206239 | 0.92 | SYK (0.39) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL24943836 | 0.92 | EML4 (0.36) | BTKSYK | |
| SCHEMBL30205999 | 0.91 | LRRK2 (0.33) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL31577321 | 0.91 | LRRK2 (0.33) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL30206019 | 0.90 | SYK (0.41) | MAPTBTKPKMYT1SYK | |
| SCHEMBL29173329 | 0.90 | SYK (0.41) | MAPTBTKPKMYT1SYK | |
| SCHEMBL29173512 | 0.88 | PKMYT1 (0.40) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL30206202 | 0.88 | PKMYT1 (0.40) | MEN1NPC1MAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |