Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205999 | 1.00 | LRRK2 (0.33) | LRRK2ADORA2AADORA1ALDH1A1BTK | |
| SCHEMBL24944436 | 0.92 | EML4 (0.36) | BTK | |
| SCHEMBL30205483 | 0.92 | EML4 (0.36) | BTK | |
| SCHEMBL30206194 | 0.91 | MEN1 (0.34) | LRRK2BTKPKMYT1MEN1NPC1 | |
| SCHEMBL29173547 | 0.91 | MEN1 (0.34) | LRRK2BTKPKMYT1MEN1NPC1 | |
| SCHEMBL30206005 | 0.91 | ALDH1A1 (0.41) | LRRK2ALDH1A1TRPV1MEN1KMT2A | |
| SCHEMBL29173373 | 0.91 | ALDH1A1 (0.41) | LRRK2ALDH1A1TRPV1MEN1KMT2A | |
| SCHEMBL30206137 | 0.90 | TTK (0.34) | LRRK2 | |
| SCHEMBL29173677 | 0.90 | TTK (0.34) | LRRK2 | |
| SCHEMBL29173715 | 0.90 | RET (0.33) | DHODHBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |