Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | JUN | P05412 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30725531 | 1.00 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1PREPAAK1GPR119 | |
| SCHEMBL30725430 | 0.86 | STK17B (0.39) | HSP90AA1HSP90AB1STK17BSTK17AALK | |
| SCHEMBL29174599 | 0.86 | STK17B (0.39) | HSP90AA1HSP90AB1STK17BSTK17AALK | |
| SCHEMBL30493899 | 0.74 | SYK (0.40) | STK17BSTK17AALKTTK | |
| SCHEMBL30260981 | 0.72 | NR1H2 (0.50) | — | |
| SCHEMBL16140209 | 0.68 | DYRK2 (0.36) | HSP90AA1HSP90AB1GPR119STK17BSTK17A | |
| SCHEMBL38663337 | 0.68 | ABL1 (0.47) | GPR119ALKABL1BCRCKS1B | |
| SCHEMBL20617903 | 0.68 | ROCK2 (0.42) | ALKTTK | |
| SCHEMBL17196938 | 0.67 | PREP (0.38) | PREPGPR119ALKABL1BCR | |
| SCHEMBL25694862 | 0.67 | STK17B (0.33) | HSP90AA1HSP90AB1AAK1GPR119STK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117430589-A | 2-aminopyrimidine compound or salt thereof, and preparation method and application thereof | 励缔(杭州)医药科技有限公司 | 2024-01-23 | — | — | CN | disclosed |