SCHEMBL29175249

SCHEMBL29175249

Cc1cc(Br)ccc1-c1ccc(Br)cc1C#N

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BIRC5 O15392 1/20 0.39
TSHR P16473 1/20 0.38
MAOB P27338 3/20 0.37
MAOA P21397 2/20 0.37
MCL1 Q07820 1/20 0.34
SLC1A5 Q15758 1/20 0.34
S100A4 P26447 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
DRD4 P21917 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HSP90AB1 P08238 1/20 0.33
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
PYCR1 P32322 1/20 0.33
CHEK1 O14757 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31310581 0.88 MAOB (0.44) MAOBMAOAMCL1SLC1A5S100A4
SCHEMBL19062226 0.88 MAOB (0.44) MAOBMAOAMCL1SLC1A5S100A4
SCHEMBL8845800 0.87 TSHR (0.47) BIRC5TSHRALDH1A1
SCHEMBL28369909 0.81 IMPDH2 (0.44) TSHR
SCHEMBL2945910 0.81 S100A4 (0.46) MCL1S100A4NPSR1ALDH1A1PYCR1
SCHEMBL28369547 0.80 TSHR (0.39) BIRC5TSHRMCL1ALDH1A1
SCHEMBL290322 0.79 TSHR (0.48) BIRC5TSHRMAOBMAOAMCL1
SCHEMBL29825887 0.79 TSHR (0.48) BIRC5TSHRMAOBMAOAMCL1
SCHEMBL290236 0.79 TSHR (0.48) TSHRMAOBMAOAMCL1NOS3
SCHEMBL8315677 0.78 CYP2A6 (0.36) BIRC5TSHRMAOBMAOAMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117723686-A Method for determining potential genotoxic impurities in telmisartan by HPLC 南京红太阳医药研究院有限公司 2024-03-19 CN disclosed