Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2473766 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL2465586 | 0.88 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL2470113 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL2467688 | 0.84 | KDM4E (0.44) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL2465785 | 0.84 | GAA (0.40) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL2472224 | 0.83 | NPC1 (0.37) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL6358742 | 0.82 | RAB9A (0.41) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL2469920 | 0.82 | GAA (0.41) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL2913904 | 0.81 | KCNA3 (0.41) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL2470303 | 0.80 | NPC1 (0.39) | SMN1; SMN2RAB9ANPC1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841741-B1 | PIPERIDINE DERIVATIVES AS PRODRUGS OF POTASSIUM CHANNEL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2010-09-08 | — | — | EP | claimed |