SCHEMBL29196358

SCHEMBL29196358

C=CCONCc1ccc(C(F)(F)F)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.41
ALDH1A1 P00352 1/20 0.41
TEAD1 P28347 1/20 0.39
TAAR1 Q96RJ0 1/20 0.38
KMT2A Q03164 2/20 0.37
MAPK14 Q16539 1/20 0.37
MEN1 O00255 1/20 0.37
SCN8A Q9UQD0 1/20 0.37
FFAR1 O14842 1/20 0.36
KDM1A O60341 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
MTOR P42345 1/20 0.36
TGM2 P21980 1/20 0.36
KCNH2 Q12809 1/20 0.35
TMEM97 Q5BJF2 1/20 0.35
LSS P48449 1/20 0.35
HDAC3 O15379 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29196384 0.77 ALDH1A1 (0.47) IDO1ALDH1A1TAAR1KMT2AMAPK14
SCHEMBL7110909 0.77 SMN1; SMN2 (0.47) IDO1ALDH1A1KMT2AMEN1
SCHEMBL23610152 0.75 ALDH1A1 (0.55) IDO1ALDH1A1KMT2AMEN1
SCHEMBL19690436 0.74 ALDH1A1 (0.44) IDO1ALDH1A1TEAD1TAAR1KMT2A
SCHEMBL6881538 0.73 ALDH1A1 (0.50) IDO1ALDH1A1TAAR1KMT2AMAPK14
SCHEMBL26027139 0.71 SCN8A (0.47) IDO1ALDH1A1TEAD1TAAR1KMT2A
SCHEMBL29196279 0.70 ALDH1A1 (0.47) IDO1ALDH1A1TAAR1KMT2AMAPK14
SCHEMBL8002836 0.70 TAAR1 (0.48) IDO1ALDH1A1TAAR1KMT2AMEN1
SCHEMBL15129318 0.70 ALDH1A1 (0.50) IDO1ALDH1A1TAAR1FFAR1KDM1A
SCHEMBL1436108 0.69 PTPN1 (0.54) IDO1ALDH1A1TAAR1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117924277-A Oxime ether compound and preparation method, pharmaceutical composition and application thereof 中国药科大学 2024-04-26 CN disclosed