Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 3/20 | 0.49 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30526637 | 0.87 | POLQ (0.63) | POLQKDM4EABL1SRCGPBAR1 | |
| SCHEMBL25306864 | 0.87 | POLQ (0.63) | POLQKDM4EABL1SRCGPBAR1 | |
| SCHEMBL29575480 | 0.84 | POLQ (0.48) | POLQGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL22717429 | 0.84 | POLQ (0.48) | POLQGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29694637 | 0.84 | POLQ (0.48) | POLQGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL30526837 | 0.77 | POLQ (0.53) | POLQCSF1RABL1 | |
| SCHEMBL30640062 | 0.77 | POLQ (0.60) | POLQHTR5ACSF1R | |
| SCHEMBL30640089 | 0.77 | POLQ (0.60) | POLQHTR5ACSF1R | |
| SCHEMBL30640087 | 0.77 | POLQ (0.60) | POLQHTR5ACSF1R | |
| SCHEMBL24770167 | 0.77 | POLQ (0.43) | POLQGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117794927-A | O-linked thiadiazolyl compounds as inhibitors of DNA polymerase theta | 伊迪亚生物科学有限公司 | 2024-03-29 | — | — | CN | disclosed |