Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL27839795 | 0.94 | RARB (0.49) | RARBTP53TSHRPLA2G4BALDH1A1 | |
| Terephthalic Acid SCHEMBL8840756 | 0.94 | RARB (0.54) | RARBTP53TSHRPLA2G4BALDH1A1 | |
| Terephthalic Acid SCHEMBL11562692 | 0.94 | RARB (0.54) | RARBTP53TSHRPLA2G4BALDH1A1 | |
| Terephthalic Acid SCHEMBL28005583 | 0.92 | TP53 (0.57) | RARBTP53TSHRPLA2G4BALDH1A1 | |
| Terephthalic Acid SCHEMBL29199869 | 0.92 | TP53 (0.57) | RARBTP53TSHRPLA2G4BALDH1A1 | |
| Benzoic Acid SCHEMBL29233380 | 0.92 | TSHR (0.52) | RARBTP53TSHRPLA2G4B | |
| Benzoic Acid SCHEMBL2463701 | 0.92 | TSHR (0.52) | RARBTP53TSHRPLA2G4B | |
| Terephthalic Acid SCHEMBL30402864 | 0.92 | TP53 (0.57) | RARBTP53TSHRPLA2G4BALDH1A1 | |
| Terephthalic Acid SCHEMBL28532097 | 0.89 | RARB (0.50) | RARBTP53TSHRPLA2G4BALDH1A1 | |
| Terephthalic Acid SCHEMBL28992734 | 0.88 | FFAR4 (0.50) | RARBTP53TSHRPLA2G4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115010908-B | Preparation method of biodegradable low-melting-point hot-melt polyester | 东华大学 | 2023-02-28 | — | — | CN | claimed |
| CN-115010908-A | Preparation method of biodegradable low-melting-point hot-melt polyester | 东华大学 | 2022-09-06 | — | — | CN | claimed |
| CN-117946649-A | Sustained-release foam discharging agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2023173791-A1 | POLYESTER MATERIAL AND POLYESTER PRODUCT, AND PREPARATION METHODS THEREFOR AND USE THEREOF | 中国科学院宁波材料技术与工程研究所 | 2023-09-21 | — | — | WO | disclosed |
| CN-115010908-B | Preparation method of biodegradable low-melting-point hot-melt polyester | 东华大学 | 2023-02-28 | — | — | CN | disclosed |
| CN-113583198-B | Polyurethane acrylate composition and application thereof | 上海康达新材料科技有限公司 | 2022-09-16 | — | — | CN | disclosed |
| CN-115010908-A | Preparation method of biodegradable low-melting-point hot-melt polyester | 东华大学 | 2022-09-06 | — | — | CN | disclosed |
| CN-115010908-A | Preparation method of biodegradable low-melting-point hot-melt polyester | 东华大学 | 2022-09-06 | — | — | CN | disclosed |
| CN-111499854-B | Preparation method of bio-based polyester | 南京工业大学 | 2022-03-11 | — | — | CN | disclosed |