Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL121153 | 0.86 | LMNA (0.53) | LMNAHPGDHIF1AHSD17B10RECQL | |
| Water SCHEMBL3002925 | 0.84 | LMNA (0.51) | LMNAHPGDHIF1AHSD17B10RECQL | |
| Ammonia Solution, Strong SCHEMBL1924833 | 0.84 | LMNA (0.51) | LMNAHPGDHIF1AHSD17B10RECQL | |
| Hydrochloric Acid SCHEMBL5858440 | 0.84 | LMNA (0.51) | LMNAHPGDHIF1AHSD17B10RECQL | |
| Ethylene Glycol SCHEMBL6331832 | 0.83 | LMNA (0.51) | LMNAHPGDHIF1AHSD17B10RECQL | |
| SCHEMBL8506852 | 0.82 | LMNA (0.51) | LMNAHPGDHIF1AHSD17B10RECQL | |
| SCHEMBL3369695 | 0.82 | LMNA (0.51) | LMNAHPGDHIF1AHSD17B10RECQL | |
| Ethylenediamine SCHEMBL8311256 | 0.81 | LMNA (0.50) | LMNAHPGDHIF1AHSD17B10RECQL | |
| 1,4-Butanediol SCHEMBL8980142 | 0.80 | LMNA (0.49) | LMNAHPGDHIF1AHSD17B10RECQL | |
| 1,3-Propanediol SCHEMBL8503984 | 0.80 | LMNA (0.49) | LMNAHPGDHIF1AHSD17B10RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225227-B1 | 1',3'-Dihydrospiro[imidazolidin-4,2'-inden]-2,5-diones and 1,3-dihydrospiro[inden-2,3']-pyrroles as CGRP antagonists | BOEHRINGER INGELHEIM INT (DE) | 2015-08-26 | — | — | EP | disclosed |
| EP-2251339-A2 | COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2010-11-17 | — | — | EP | disclosed |
| EP-2225227-A2 | COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009065920-A2 | NOVEL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-28 | — | — | WO | disclosed |