SCHEMBL29200375

SCHEMBL29200375

O=C(Nc1ccc(CCl)cc1)Nc1cccc(F)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.63
MEN1 O00255 7/20 0.63
KMT2A Q03164 7/20 0.63
MTOR P42345 2/20 0.62
NPC1 O15118 6/20 0.59
MAPT P10636 3/20 0.59
GAA P10253 1/20 0.57
CASP3 P42574 1/20 0.56
SENP7 Q9BQF6 1/20 0.56
TAAR1 Q96RJ0 1/20 0.55
MARS1 P56192 1/20 0.53
TSHR P16473 1/20 0.53
SAE1 Q9UBE0 1/20 0.52
UBA2 Q9UBT2 1/20 0.52
LMNA P02545 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
CNR1 P21554 1/20 0.51
GBA1 P04062 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29200400 0.89 RAB9A (0.65) RAB9AMEN1KMT2AMTORNPC1
SCHEMBL30802661 0.89 RAB9A (0.65) RAB9AMEN1KMT2AMTORNPC1
SCHEMBL29200431 0.86 MTOR (0.64) RAB9AMEN1KMT2AMTORNPC1
Urea SCHEMBL29200424 0.85 KMT2A (0.60) RAB9AMEN1KMT2AMTORNPC1
SCHEMBL4124075 0.85 RAB9A (0.68) RAB9AMEN1KMT2AMTORNPC1
SCHEMBL30851500 0.83 RAB9A (0.79) RAB9AMEN1KMT2AMTORNPC1
SCHEMBL27193042 0.83 RAB9A (0.79) RAB9AMEN1KMT2AMTORNPC1
SCHEMBL29200426 0.83 MEN1 (0.72) RAB9AMEN1KMT2AMTORNPC1
SCHEMBL12218440 0.83 RAB9A (0.79) RAB9AMEN1KMT2AMTORNPC1
SCHEMBL4116592 0.82 MEN1 (0.60) RAB9AMEN1KMT2AMTORNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117658868-A Benzamide derivative and preparation method and application thereof 中山大学 2024-03-08 CN disclosed