Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.47 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5275078 | 0.93 | DNM1 (0.55) | DNM1CA2GPR84CA1FFAR1 | |
| Acetic Acid SCHEMBL5673150 | 0.91 | DNM1 (0.68) | DNM1CA2GPR84CA1FFAR1 | |
| Acetic Acid SCHEMBL11044320 | 0.91 | DNM1 (0.68) | DNM1CA2GPR84CA1FFAR1 | |
| Acetic Acid SCHEMBL31730241 | 0.91 | DNM1 (0.68) | DNM1CA2GPR84CA1FFAR1 | |
| Bicarbonate SCHEMBL28469661 | 0.91 | DNM1 (0.67) | DNM1CA2GPR84CA1FFAR1 | |
| Oxalic Acid SCHEMBL11422824 | 0.89 | DNM1 (0.58) | DNM1CA2GPR84CA1FFAR1 | |
| Acetic Acid SCHEMBL7929476 | 0.89 | DNM1 (0.58) | DNM1CA2GPR84CA1FFAR1 | |
| Oxalic Acid SCHEMBL11422811 | 0.88 | DNM1 (0.64) | DNM1CA2GPR84CA1FFAR1 | |
| Acetic Acid SCHEMBL17839027 | 0.88 | DNM1 (0.64) | DNM1CA2GPR84CA1FFAR1 | |
| Acetic Acid SCHEMBL1032589 | 0.88 | DNM1 (0.64) | DNM1CA2GPR84CA1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813334-A | Onium salt, blocking agent dissociation catalyst for blocking isocyanate, blocked isocyanate composition containing blocking agent dissociation catalyst, thermosetting resin composition, cured product, and method for producing same | 广荣化学株式会社 | 2024-04-02 | — | — | CN | disclosed |