Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29201727 | 1.00 | SIGMAR1 (0.46) | SIGMAR1LMNAGAAKDM4EATM | |
| SCHEMBL29201698 | 0.87 | LMNA (0.58) | LMNAGAAKDM4ECYP2D6CYP2C9 | |
| SCHEMBL29201720 | 0.87 | LMNA (0.58) | LMNAGAAKDM4ECYP2D6CYP2C9 | |
| SCHEMBL29201716 | 0.85 | SIGMAR1 (0.45) | SIGMAR1LMNAGAAKDM4EATM | |
| SCHEMBL29201714 | 0.85 | SIGMAR1 (0.45) | SIGMAR1LMNAGAAKDM4EATM | |
| SCHEMBL30864070 | 0.73 | SIGMAR1 (0.60) | SIGMAR1LMNAGAAKDM4EATM | |
| SCHEMBL30816869 | 0.73 | SIGMAR1 (0.60) | SIGMAR1LMNAGAAKDM4EATM | |
| SCHEMBL30816895 | 0.73 | SIGMAR1 (0.60) | SIGMAR1LMNAGAAKDM4EATM | |
| SCHEMBL8435472 | 0.72 | TACR1 (0.53) | SIGMAR1LMNAGAAMEN1KMT2A | |
| SCHEMBL1126489 | 0.72 | SIGMAR1 (0.69) | SIGMAR1LMNAGAAKDM4EMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917410-A | Pan-KRAS degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |