Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12781846 | 1.00 | KDM4E (0.66) | KDM4EADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL7269243 | 0.86 | KDM4E (0.66) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL12858908 | 0.85 | KDM4E (0.64) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL7298012 | 0.83 | KDM4E (0.57) | KDM4EADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL18159894 | 0.82 | KDM4E (0.60) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL7357510 | 0.82 | KDM4E (0.56) | KDM4EADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL30816895 | 0.81 | SIGMAR1 (0.60) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL30864070 | 0.81 | SIGMAR1 (0.60) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL21164624 | 0.81 | KDM4E (0.64) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL30816869 | 0.81 | SIGMAR1 (0.60) | KDM4ELMNAGAASIGMAR1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |