Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29201748 | 0.86 | KDM4E (0.66) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL12781846 | 0.86 | KDM4E (0.66) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL12858908 | 0.85 | KDM4E (0.64) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL18159894 | 0.82 | KDM4E (0.60) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL10572259 | 0.81 | ADRA2A (0.73) | KDM4EGAAIGF1RALDH1A1DRD4 | |
| SCHEMBL7523946 | 0.81 | SMN1; SMN2 (0.60) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL24672242 | 0.81 | KDM4E (0.68) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL1394535 | 0.81 | KDM4E (0.68) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL21797152 | 0.81 | KDM4E (0.68) | KDM4ELMNAGAASIGMAR1IGF1R | |
| SCHEMBL1394539 | 0.81 | KDM4E (0.68) | KDM4ELMNAGAASIGMAR1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35072-E | Cardiotonic agents and antiarrhythmic agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-10-24 | — | — | US | disclosed |
| US-5405847-A | Antiallergic, antiasthmatic, anxiolytic, hypotensive agents | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1995-04-11 | — | — | US | disclosed |
| EP-0584487-A2 | 4,5-Dihydro-4-oxopyrrolo (1,2-a) quinoxalines and aza-analoges and process for their preparation | ASTA Medica Aktiengesellschaft (DE) | 1994-03-02 | — | — | EP | disclosed |
| US-5252569-A | Cardiotonic, antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0331511-B1 | 6-SUBSTITUTED PURINYL PIPERAZINE DERIVATIVES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5164390-A | Cardiac disorders | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0458618-A1 | 6-Substituted purinyl piperazine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5021574-A | Cardiotonic agents, antiarrhythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-06-04 | — | — | US | disclosed |
| US-5001127-A | 4-substituted pyrazolo[3,4-d]pyrimidine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-03-19 | — | — | US | disclosed |
| US-4885300-A | CARDIOTONIC AND ANTIARRHYTHMIA AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-12-05 | — | — | US | disclosed |
| US-4876257-A | 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0331510-A2 | 4-Substituted pyrazolo[3,4-d]pyrimidine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-09-06 | — | — | EP | disclosed |
| EP-0331511-A1 | 6-Substituted purinyl piperazine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-09-06 | — | — | EP | disclosed |