Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 9/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30816855 | 1.00 | DDB1 (0.47) | DDB1CRBNGAATNKSKDM4E | |
| SCHEMBL29606903 | 0.85 | DDB1 (0.58) | DDB1CRBNGAATNKSKDM4E | |
| SCHEMBL21409149 | 0.85 | DDB1 (0.58) | DDB1CRBNGAATNKSKDM4E | |
| SCHEMBL21408861 | 0.84 | TSHR (0.48) | DDB1CRBNKDM4EALDH1A1HPGD | |
| SCHEMBL30148827 | 0.84 | TSHR (0.48) | DDB1CRBNKDM4EALDH1A1HPGD | |
| SCHEMBL23120783 | 0.83 | MYC (0.47) | DDB1CRBNGAATNKSKDM4E | |
| SCHEMBL29607697 | 0.83 | MYC (0.47) | DDB1CRBNGAATNKSKDM4E | |
| SCHEMBL21409269 | 0.82 | CRBN (0.45) | DDB1CRBNGAATNKSKDM4E | |
| SCHEMBL21409088 | 0.82 | ALDH1A1 (0.47) | DDB1CRBNGAATNKSKDM4E | |
| SCHEMBL29606876 | 0.82 | CRBN (0.45) | DDB1CRBNGAATNKSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024083258-A1 | KRAS G12C DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | 上海领泰生物医药科技有限公司 | 2024-04-25 | — | — | WO | disclosed |
| CN-117917410-A | Pan-KRAS degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |