Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Abeprazan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Abeprazan SCHEMBL29443418 | 0.97 | HTR6 (0.39) | HTR6MAPTDRD2HTR2AMEN1 | |
| Abeprazan SCHEMBL29719476 | 0.97 | HTR6 (0.39) | HTR6MAPTDRD2HTR2AMEN1 | |
| Abeprazan SCHEMBL18196939 | 0.97 | HTR6 (0.39) | HTR6MAPTDRD2HTR2AMEN1 | |
| Abeprazan SCHEMBL19385615 | 0.96 | HTR6 (0.40) | HTR6MAPTDRD2HTR2AMEN1 | |
| Abeprazan SCHEMBL29201774 | 0.94 | HTR6 (0.37) | HTR6MAPTDRD2HTR2AMEN1 | |
| Abeprazan SCHEMBL19385601 | 0.93 | FABP4 (0.38) | HTR6MAPTDRD2HTR2AMEN1 | |
| Abeprazan SCHEMBL19385619 | 0.92 | HTR6 (0.37) | HTR6MAPTDRD2HTR2AMEN1 | |
| Abeprazan SCHEMBL19385623 | 0.91 | FABP4 (0.37) | HTR6MAPTDRD2HTR2AMEN1 | |
| Abeprazan SCHEMBL29201783 | 0.91 | FABP4 (0.37) | HTR6MAPTDRD2FABP4FABP5 | |
| SCHEMBL18190937 | 0.91 | HTR6 (0.35) | HTR6DRD2HTR2AMEN1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117756695-A | Novel crystalline forms of highly water-soluble salts of novel 4-methoxypyrrole derivatives | 罗欣药业(上海)有限公司 | 2024-03-26 | — | — | CN | disclosed |