Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 3/20 | 0.35 |
| ▸ | ESRRB | O95718 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29203471 | 0.83 | KDM4E (0.41) | TSHRKDM4ERECQLTDP1USP2 | |
| SCHEMBL29203340 | 0.80 | KDM4E (0.41) | TSHRKDM4ERECQLTDP1ALDH1A1 | |
| SCHEMBL30240828 | 0.80 | KDM4E (0.41) | TSHRKDM4ERECQLTDP1ALDH1A1 | |
| SCHEMBL29203341 | 0.80 | KDM4E (0.41) | TSHRKDM4ERECQLTDP1ALDH1A1 | |
| SCHEMBL24933238 | 0.73 | TSHR (0.37) | TSHRKDM4ERECQLTDP1ALDH1A1 | |
| SCHEMBL29203483 | 0.71 | TSHR (0.44) | TSHRKDM4ERECQLTDP1ALDH1A1 | |
| SCHEMBL24933240 | 0.71 | TSHR (0.36) | TSHRKDM4ERECQLTDP1ALDH1A1 | |
| SCHEMBL15301046 | 0.71 | TSHR (0.41) | TSHRKDM4ETDP1ALDH1A1 | |
| SCHEMBL29203469 | 0.70 | TSHR (0.43) | TSHRKDM4ERECQLTDP1ALDH1A1 | |
| SCHEMBL29203467 | 0.70 | DPP4 (0.34) | TSHRKDM4EALDH1A1USP2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |