Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.71 |
| ▸ | GSK3A | P49840 | 5/20 | 0.71 |
| ▸ | PRKCA | P17252 | 2/20 | 0.71 |
| ▸ | RGS4 | P49798 | 8/20 | 0.68 |
| ▸ | RGS8 | P57771 | 8/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29210516 | 0.85 | RGS4 (0.63) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL29239064 | 0.82 | RGS4 (0.75) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL29210519 | 0.82 | RGS4 (0.75) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL29210532 | 0.81 | GSK3B (0.68) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL23763661 | 0.81 | RGS4 (0.73) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL29210530 | 0.81 | RGS4 (0.73) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL13517254 | 0.81 | RGS4 (1.00) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL29210526 | 0.81 | RGS4 (0.73) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL29210480 | 0.80 | RGS4 (0.56) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL29210583 | 0.79 | RGS4 (0.55) | GSK3BGSK3APRKCARGS4RGS8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117986202-B | 1,2, 4-Thiadiazolidine-3, 5-dione compound with PTPN2 inhibitory activity, and preparation method and application thereof | 中国药科大学 | 2024-06-14 | — | — | CN | disclosed |
| CN-117986202-A | 1,2, 4-Thiadiazolidine-3, 5-dione compound with PTPN2 inhibitory activity, and preparation method and application thereof | 中国药科大学 | 2024-05-07 | — | — | CN | disclosed |