Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS4 | P49798 | 4/20 | 0.55 |
| ▸ | RGS8 | P57771 | 4/20 | 0.55 |
| ▸ | GSK3B | P49841 | 5/20 | 0.54 |
| ▸ | GSK3A | P49840 | 3/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PARG | Q86W56 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29210480 | 0.87 | RGS4 (0.56) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL29210485 | 0.79 | GSK3B (0.71) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL29210516 | 0.76 | RGS4 (0.63) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL10260239 | 0.74 | SIGMAR1 (0.62) | HPGDSIGMAR1ALDH1A1CCNCCDK8 | |
| Hydrochloric Acid SCHEMBL25324901 | 0.73 | HPGD (0.63) | HPGDSIGMAR1ALDH1A1CCNCCDK8 | |
| SCHEMBL29239064 | 0.73 | RGS4 (0.75) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL29210519 | 0.73 | RGS4 (0.75) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL20245216 | 0.72 | SIGMAR1 (0.58) | HPGDSIGMAR1ALDH1A1CCNCCDK8 | |
| SCHEMBL29210530 | 0.72 | RGS4 (0.73) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL29210526 | 0.72 | RGS4 (0.73) | RGS4RGS8GSK3BGSK3APRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117986202-B | 1,2, 4-Thiadiazolidine-3, 5-dione compound with PTPN2 inhibitory activity, and preparation method and application thereof | 中国药科大学 | 2024-06-14 | — | — | CN | disclosed |
| CN-117986202-A | 1,2, 4-Thiadiazolidine-3, 5-dione compound with PTPN2 inhibitory activity, and preparation method and application thereof | 中国药科大学 | 2024-05-07 | — | — | CN | disclosed |