Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.60 |
| ▸ | CETP | P11597 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292370 | 0.91 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DCETP | |
| SCHEMBL357498 | 0.77 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL291798 | 0.77 | PDE4A (0.96) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3322406 | 0.75 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCETP | |
| SCHEMBL292710 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29824397 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3322237 | 0.71 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL3322428 | 0.71 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6397973 | 0.71 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL10709061 | 0.70 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029600-B1 | SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBERED HETEROCYCLE | BOEHRINGER INGELHEIM INT (DE) | 2012-03-14 | — | — | EP | disclosed |