Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 3/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292108 | 0.91 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL357498 | 0.85 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DHRH4 | |
| SCHEMBL291798 | 0.78 | PDE4A (0.96) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL3322428 | 0.77 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL3322237 | 0.77 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL292710 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL29824397 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL3322406 | 0.74 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCETP | |
| SCHEMBL16160252 | 0.74 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6397973 | 0.73 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029600-B1 | SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBERED HETEROCYCLE | BOEHRINGER INGELHEIM INT (DE) | 2012-03-14 | — | — | EP | disclosed |
| EP-2029600-B1 | SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBERED HETEROCYCLE | BOEHRINGER INGELHEIM INT (DE) | 2012-03-14 | — | — | EP | disclosed |
| US-20100234347-A1 | Substituted Pteridines substituted with a Four-Membered Heterocycle | BOEHRINGER INGELHEIM INTERNATIONL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234347-A1 | Substituted Pteridines substituted with a Four-Membered Heterocycle | BOEHRINGER INGELHEIM INTERNATIONL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234347-A1 | Substituted Pteridines substituted with a Four-Membered Heterocycle | BOEHRINGER INGELHEIM INTERNATIONL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| WO-2007135027-A1 | SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBERED HETEROCYCLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234347-A1 | Substituted Pteridines substituted with a Four-Membered Heterocycle | UACA, LTC4S, PMP22 | PDE4A 1509/4885PDE4B 1446/4885PDE4C 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.