SCHEMBL29211663

SCHEMBL29211663

CN1CCN(CCCN)CC1.ClCOc1ccc2c(OCCl)c3ccccc3nc2c1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 2/20 0.46
HRH3 Q9Y5N1 1/20 0.46
KDM1A O60341 1/20 0.43
XDH P47989 1/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
HRH4 Q9H3N8 1/20 0.40
FLT3 P36888 1/20 0.40
AURKA O14965 1/20 0.40
AURKB Q96GD4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4957181 0.80 KMT2A (0.46) KDM1ANPC1RAB9A
SCHEMBL29211664 0.79 SIGMAR1 (0.44) HRH3
SCHEMBL8410663 0.71 CASP7 (0.55) KDM1ARAB9A
SCHEMBL19260720 0.70 HRH3 (0.54) HRH3XDH
SCHEMBL10810010 0.69 HRH3 (0.74) DRD3HRH3XDHNPC1RAB9A
SCHEMBL19260636 0.68 HRH3 (0.56) HRH3XDH
SCHEMBL19260828 0.68 HRH3 (0.54) HRH3XDH
SCHEMBL10807692 0.67 HRH3 (0.70) DRD3HRH3XDHNPC1RAB9A
SCHEMBL22855777 0.65 HRH3 (0.76) HRH3NPC1RAB9A
SCHEMBL19260826 0.65 HRH3 (0.51) HRH3XDHAURKAAURKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115286574-B BLVRB enzyme function inhibitor and preparation method and application thereof 吉林医药学院 2023-07-11 CN disclosed