Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 4/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30896204 | 1.00 | ATR (0.39) | ATRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6523050 | 0.85 | ATR (0.40) | ATRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL30038713 | 0.84 | CYP17A1 (0.40) | ATRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL28459659 | 0.84 | CYP17A1 (0.40) | ATRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL22684078 | 0.78 | CYP17A1 (0.38) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL24427976 | 0.78 | CYP17A1 (0.42) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL660566 | 0.77 | NLRP3 (0.43) | ATRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL439559 | 0.76 | LMNA (0.44) | ATRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL30710105 | 0.75 | LCK (0.42) | ATRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL26694465 | 0.75 | LCK (0.42) | ATRNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119948029-A | Fused tricyclic PARP1 inhibitor, preparation method and application thereof | 上海海和药物研究开发股份有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-118005637-A | Fused tricyclic PARP1 inhibitor, preparation method and application thereof | 上海海和药物研究开发股份有限公司 | 2024-05-10 | — | — | CN | disclosed |