Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 11/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.40 |
| ▸ | GRN | P28799 | 3/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30903296 | 1.00 | PDCD1 (0.40) | PDCD1CD274GRNSORT1PYGL | |
| SCHEMBL29213332 | 1.00 | PDCD1 (0.40) | PDCD1CD274GRNSORT1PYGL | |
| SCHEMBL29213242 | 0.83 | KMT2A (0.41) | GRNSORT1CYP2C9KMT2AFNTA | |
| SCHEMBL29213243 | 0.83 | KMT2A (0.41) | GRNSORT1CYP2C9KMT2AFNTA | |
| SCHEMBL29213443 | 0.81 | ROS1 (0.43) | KMT2AKDM4EALDH1A1TDP1 | |
| SCHEMBL29213441 | 0.81 | ROS1 (0.43) | KMT2AKDM4EALDH1A1TDP1 | |
| SCHEMBL30903311 | 0.79 | MMP1 (0.45) | GRNSORT1ALDH1A1 | |
| SCHEMBL29213402 | 0.79 | NSD2 (0.42) | GRNSORT1KMT2AFNTAFNTB | |
| SCHEMBL29213398 | 0.79 | NSD2 (0.42) | GRNSORT1KMT2AFNTAFNTB | |
| SCHEMBL29213464 | 0.79 | MMP1 (0.45) | GRNSORT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | disclosed |