Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 5/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.43 |
| ▸ | GGT1 | P19440 | 2/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | CPB1 | P15086 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29213329 | 1.00 | GRN (0.43) | GRNSORT1GGT1VNN1PDCD1 | |
| SCHEMBL29213352 | 0.84 | GRN (0.42) | GRNSORT1GGT1PDCD1CD274 | |
| SCHEMBL29213347 | 0.84 | GRN (0.42) | GRNSORT1GGT1PDCD1CD274 | |
| SCHEMBL30903312 | 0.84 | GRN (0.42) | GRNSORT1GGT1PDCD1CD274 | |
| SCHEMBL29213469 | 0.84 | GRN (0.42) | GRNSORT1GGT1PDCD1CD274 | |
| SCHEMBL29213281 | 0.84 | LMNA (0.47) | CYP2C9 | |
| SCHEMBL29213472 | 0.84 | GRN (0.42) | GRNSORT1GGT1PDCD1CD274 | |
| SCHEMBL30903298 | 0.84 | LMNA (0.47) | CYP2C9 | |
| SCHEMBL29213277 | 0.84 | LMNA (0.47) | CYP2C9 | |
| SCHEMBL29213280 | 0.83 | RAB9A (0.44) | GRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | disclosed |