Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586090 | 0.71 | PDE3B (0.47) | PDE3BPDE3APDE2AP2RY12TYRO3 | |
| SCHEMBL5786187 | 0.69 | SIRT2 (0.60) | GALR3KDM4EPDE3BPDE3APDE2A | |
| SCHEMBL1502964 | 0.69 | PDE3B (0.50) | KDM4EPDE3BPDE3APDE2AP2RY12 | |
| SCHEMBL1592898 | 0.66 | KDM4E (0.41) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL16939766 | 0.66 | PDE3B (0.44) | PDE3BPDE3APDE2AP2RY12TYRO3 | |
| SCHEMBL1163700 | 0.66 | SIRT2 (0.64) | PDE3BPDE3APDE2AP2RY12TYRO3 | |
| SCHEMBL29703027 | 0.64 | PDE3B (0.41) | PDE3BPDE3APDE2AP2RY12TYRO3 | |
| SCHEMBL8014109 | 0.64 | KDM4E (0.43) | KDM4EGAAMAPTMEN1APEX1 | |
| SCHEMBL20777269 | 0.64 | ADORA3 (0.57) | KDM4EGAAPDE3BPDE3APDE2A | |
| SCHEMBL1842652 | 0.64 | GRIA1 (0.79) | CA12CA9MAPTMEN1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117820236-A | Histone acetyltransferase small molecule inhibitor and preparation method and application thereof | 复旦大学 | 2024-04-05 | — | — | CN | disclosed |