SCHEMBL8014109

SCHEMBL8014109

O=[N+]([O-])c1ccc2[nH]nnc2n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 6/20 0.40
NOS1 P29475 4/20 0.40
POLB P06746 1/20 0.40
MAOB P27338 1/20 0.40
CYP3A4 P08684 3/20 0.37
LMNA P02545 1/20 0.37
ALOX15 P16050 1/20 0.37
TDP1 Q9NUW8 2/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
THRB P10828 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
APEX1 P27695 1/20 0.33
NOS3 P29474 1/20 0.33
CYP2C19 P33261 1/20 0.33
NOS2 P35228 1/20 0.33
RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL271615 0.67
SCHEMBL5252596 0.67
SCHEMBL1421802 0.67 NOS1 (0.35) NOS1
SCHEMBL45555 0.67 KDM4E (0.35) KDM4EGAAMAPTNOS1TDP1
SCHEMBL9996915 0.67 GAA (0.41) GAANOS1CYP1A2NOS2KMT2A
SCHEMBL1673907 0.67 SIRT2 (0.38) NOS1KMT2A
SCHEMBL17326272 0.67 TRPA1 (0.33) CYP3A4CYP2C19
SCHEMBL3293293 0.66 MAPT (0.39) KDM4EGAAMAPTPOLBLMNA
SCHEMBL27647699 0.66 TDP1 (0.44) KDM4EMAPTNOS1POLBMAOB
SCHEMBL1592898 0.66 KDM4E (0.41) KDM4EGAAMAPTNOS1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111465603-B Triazolopyridines as gamma secretase modulators 勃林格殷格翰国际有限公司 2024-01-09 CN disclosed
CN-111465603-A Triazolopyridines as gamma-secretase modulators 勃林格殷格翰国际有限公司 2020-07-28 CN disclosed
EP-0480264-B1 Silver halide photographic material and image forming method using that material FUJI PHOTO FILM CO LTD (JP) 2000-02-09 EP disclosed
EP-0479156-B1 Silver halide photographic materials FUJI PHOTO FILM CO LTD (JP) 1994-01-12 EP disclosed
US-5273859-A Containing a hydrazine derivative redox compound; using a developer containing sulfite and having a pH of 9-12 FUJI PHOTO FILM CO., LTD. (JP) 1993-12-28 US disclosed
US-5252438-A For forming ultra hard negatives; nucleating development inhibitor hydrazines FUJI PHOTO FILM CO., LTD. (JP) 1993-10-12 US disclosed
EP-0480264-A1 Silver halide photographic material and image forming method using that material FUJI PHOTO FILM CO., LTD. (JP) 1992-04-15 EP disclosed
EP-0479156-A1 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1992-04-08 EP disclosed