Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | POLB | P06746 | 6/20 | 0.72 |
| ▸ | APEX1 | P27695 | 4/20 | 0.72 |
| ▸ | RECQL | P46063 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.72 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | NSD2 | O96028 | 2/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.59 |
| ▸ | ALPL | P05186 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29214838 | 1.00 | MAPT (0.72) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL3892662 | 0.89 | MAPT (0.92) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL19420115 | 0.89 | MAPT (0.92) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL3892665 | 0.89 | MAPT (0.92) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL3893463 | 0.84 | MAPT (1.00) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL3893459 | 0.84 | MAPT (1.00) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL8181657 | 0.83 | KDR (0.69) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL8181654 | 0.83 | KDR (0.69) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL14560450 | 0.82 | MEN1 (0.64) | MAPTMEN1KMT2APOLBAPEX1 | |
| SCHEMBL29214806 | 0.82 | MMP1 (0.67) | MAPTKMT2APOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777049-B | Thiazolidinedione HDAC inhibitor, preparation method and application | 南京市鸿舜医药科技有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117777049-A | Thiazolidinedione HDAC inhibitor, preparation method and application | 南京市鸿舜医药科技有限公司 | 2024-03-29 | — | — | CN | disclosed |