SCHEMBL29215014

SCHEMBL29215014

COc1cc(C(=O)Nc2c(C)cc(Cl)cc2C(N)=O)n(-c2ncccc2Cl)n1

nearest known ligand 0.67

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
DHODH Q02127 3/20 0.37
MALT1 Q9UDY8 8/20 0.37
RBP4 P02753 1/20 0.36
NTRK1 P04629 2/20 0.36
CHRNA7 P36544 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31059992 0.93 DHODH (0.38) ALDH1A1HPGDDHODHMALT1RBP4
SCHEMBL31060014 0.91 DHODH (0.39) ALDH1A1HPGDDHODHMALT1RBP4
SCHEMBL29215156 0.91 DHODH (0.38) ALDH1A1HPGDRAB9ASMN1; SMN2DHODH
SCHEMBL31060054 0.90 DHODH (0.40) DHODHMALT1RBP4NTRK1
SCHEMBL25233715 0.90 DHODH (0.41) DHODHMALT1
SCHEMBL31060012 0.90 NTRK1 (0.38) ALDH1A1HPGDRAB9ASMN1; SMN2DHODH
SCHEMBL29215215 0.90 PDE4B (0.38) DHODHMALT1RBP4CHRNA7
SCHEMBL15971848 0.90 NTRK1 (0.38) ALDH1A1HPGDRAB9ASMN1; SMN2DHODH
SCHEMBL15984455 0.89 DHODH (0.44) ALDH1A1HPGDRAB9ASMN1; SMN2DHODH
SCHEMBL31060097 0.89 DHODH (0.44) ALDH1A1HPGDRAB9ASMN1; SMN2DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240308988-A1 Method For Controlling Diamide Resistant Pests and Compounds Therefor SYNGENTA CROP PROTECTION AG (CH) 2024-09-19 US disclosed
EP-4380363-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR Syngenta Crop Protection AG (CH) 2024-06-12 EP disclosed
CN-118076228-A Methods for controlling diamide-resistant pests and compounds thereof 先正达农作物保护股份公司 2024-05-24 CN disclosed
WO-2023012081-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR SYNGENTA CROP PROTECTION AG (CH) 2023-02-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240308988-A1 Method For Controlling Diamide Resistant Pests and Compounds Therefor DDT, NOS1, SLC11A2 ALDH1A1 784/4885HPGD 2464/4885RAB9A 2456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.