Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 3/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31128947 | 0.78 | KMT2A (0.35) | FLT3L3MBTL1 | |
| SCHEMBL15330085 | 0.76 | BRD4 (0.34) | BRD4CREBBPJAK1JAK3JAK2 | |
| SCHEMBL31128801 | 0.75 | ABL1 (0.36) | ABL1JAK1JAK3JAK2TYK2 | |
| SCHEMBL31128872 | 0.74 | CHRNB2 (0.33) | JAK1JAK3JAK2TYK2FLT3 | |
| SCHEMBL29217173 | 0.73 | FFAR1 (0.46) | ABL1JAK1JAK3JAK2TYK2 | |
| SCHEMBL553466 | 0.73 | ALDH1A1 (0.41) | JAK1JAK3JAK2TYK2L3MBTL1 | |
| SCHEMBL3491600 | 0.72 | KDM4C (0.33) | BRD4L3MBTL1 | |
| SCHEMBL29267533 | 0.72 | GAA (0.32) | — | |
| SCHEMBL31128893 | 0.72 | ABL1 (0.39) | ABL1JAK1JAK3JAK2TYK2 | |
| SCHEMBL31128903 | 0.71 | ABL1 (0.34) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084892-A | Compounds useful as HPK1 inhibitors | 深圳福沃药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117946093-A | Compounds useful as HPK1 inhibitors | 深圳福沃药业有限公司 | 2024-04-30 | — | — | CN | disclosed |